How does quinoa have an effect on the intestine microbiome of males?

Though a excessive consumption of complete grain meals reduces the danger of cardiometabolic illnesses, weight problems, kind 2 diabetes, and sure sorts of cancers, the underlying mechanism behind this incidence is unclear. Complete grain meals are typically more healthy on account of their excessive dietary fiber and phytoconstituents, sometimes misplaced throughout refining.

Examine: Influence of Every day Consumption of Complete-Grain Quinoa-Enriched Bread on Intestine Microbiome in Males. Picture Credit score: Subbotina Anna / Shutterstock


Quinoa belongs to the Polygonaceae household and has been categorized as a complete grain. In comparison with different cereals, it has a excessive protein content material, soluble and insoluble fibers, and carbohydrates that take longer to digest. Moreover, quinoa incorporates a excessive focus of conjugated, free, and certain (poly)phenolics, equivalent to saponins.

Quinoa’s skill to move via the higher gastrointestinal tract (GIT) and ultimately attain the decrease GIT, house to the intestine microbiome, is considered one of its important properties. Upon reaching the decrease GIT, quinoa undergoes fermentation by the intestine microbiome and, subsequently, produces merchandise equivalent to certain (poly) phenolics, short-chain fatty acids (SCFA), and different phytochemicals. The host makes use of these merchandise throughout their metabolic features.

Within the final decade, on account of developments in technological, molecular, and computational strategies, the intestine microbiome has attracted a lot consideration. Earlier research utilizing the aforementioned developments have revealed the existence of a posh symbiotic relationship between intestine microbes and hosts. The intestine microbiome assists within the host’s digestion, absorption, and fermentation of dietary fiber and different meals parts. Therefore, the digestion course of is dependent upon the composition of the intestine microbiome.

In regards to the Examine

Pre-clinical research have proven that quinoa consumption can modulate the intestine microbiome and scale back blood glucose when ingested in a wheat flour bread matrix. A latest Vitamins journal research assessed the intestine microbiome adjustments after consuming quinoa-enriched bread in a randomized cross-over trial.

The present cross-over trial included two remedy durations consisting of 4 weeks, separated by a 4 weeks washout interval. All of the members have been above 35 years of age, non-smokers, and weren’t beneath any remedy.

As part of the experimental design, the remedy group members got one quinoa-enriched bread roll per day, whereas the management group, or these subjected to placebo remedy, acquired a bread roll containing no quinoa. As well as, though members have been advisable typical diets, they have been requested to not devour any whole-grain meals throughout the research interval.

Blood and stool samples have been collected throughout the research interval, i.e., in the beginning of every 4-week remedy interval. DNA was extracted from stool samples and subjected to 16S rRNA sequencing.

Examine Findings

A complete of 37 male members enrolled on this research, amongst which 9 dropped out throughout the research interval. The imply age of the members was 51.5 years, and the typical physique mass index (BMI) was 27.7 kg/m2

The BMI, blood strain, and fasting blood glucose of all members remained unchanged throughout the research interval. The quinoa bread and management bread contained 6.52 g/100 g and three.60 g/100 g of dietary fiber, respectively.

Principle coordinate analysis (PcoA) of unweighted UniFrac analysis and weighted UniFrac analysis pre- (baseline) and post-consumption (post) for quinoa and control wheat bread pre-baseline and week 4.Precept coordinate evaluation (PcoA) of unweighted UniFrac evaluation and weighted UniFrac evaluation pre- (baseline) and post-consumption (submit) for quinoa and management wheat bread pre-baseline and week 4.

The stool samples have been in comparison with assess the affect of the quinoa and the management wheat bread on the intestine microbiome. Apparently, the intestine microbiome profiles developed within the present research indicated the same composition to any grownup human stool pattern. Two of the dominant bacterial phyla current within the stool samples have been bacteroidetes and firmicutes.

The management and remedy teams noticed a non-significant enhance of firmicutes, by round 7.5% and 4.4%, respectively. Equally, a non-significant discount within the bacteroidetes stage was noticed between the 2 teams. A rise in Fusicatenibacter (1.4%) and Subdoligranulum (1.9%) was discovered within the management group. In distinction, adjustments in genera Anaerostipes and Dorea have been noticed within the quinoa bread-consuming group. Nevertheless, none of those adjustments have been statistically important.

Each the management and remedy teams revealed no important adjustments in α-diversity between baseline and week 4. This research estimated α-diversity by evaluating the variety of observational taxonomic models (OTU) earlier than and after the remedy durations.

The findings of this research contradicted a earlier pre-clinical animal model-based research that indicated statistically important adjustments in bacterial composition on account of quinoa consumption. Nonetheless, the findings have been in step with one other earlier research the place sufferers with elevated dietary fiber consumption by way of the consumption of various kinds of complete grains confirmed no adjustments in microbial range metrics.


The present research revealed that 4 weeks of consuming quinoa-enriched bread didn’t alter particular micro organism phyla and genera composition or the α-diversity of the intestine microbiome. Sooner or later, extra analysis is required to grasp higher whether or not a particular dosage of quinoa might alter the intestine microbiome and if these alterations result in physiological well being advantages.

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